Description
| Product Name: | Human DCUN1D1 Recombinant Protein |
| Product Code: | RPPB3340 |
| Size: | 20µg |
| Species: | Human |
| Target: | DCUN1D1 |
| Synonyms: | DCN1, defective in cullin neddylation 1-domain containing 1 (S. cerevisiae), RP42, DCUN1L1, SCCRO, SCRO, Tes3, Defective in cullin neddylation protein 1-like protein 1, Squamous cell carcinoma-related oncogene, DCUN1 domain-containing protein 1, DCN1-like protein 1, RP42 homolog. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The DCUN1D1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI DDFVEFARPQ IAGTKSTTV |
DCUN1D1 takes part in the malignant transformation of squamous cell lineage. DCUN1D1 protein regulates Gli1, a main regulator of the hedgehog (HH) pathway which takes a vital role in development, maintenance, and regeneration of practically all adult tissues.
DCUN1D1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 279 amino acids (1-259a.a.) and having a molecular mass of 32.2kDa. DCUN1D1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DCUN1D1: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. |
| UniProt Protein Details: | Protein type:Oncoprotein; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3q26.3 Cellular Component: nucleus; ubiquitin ligase complex Molecular Function:protein binding; small conjugating protein binding; ubiquitin conjugating enzyme binding Biological Process: positive regulation of ubiquitin-protein ligase activity; protein neddylation |
| UniProt Code: | Q96GG9 |
| NCBI GenInfo Identifier: | 809281410 |
| NCBI Gene ID: | 54165 |
| NCBI Accession: | NP_001295030.1 |
| UniProt Secondary Accession: | Q96GG9,Q7L3G9, Q8TEX7, Q9H6M1, Q9HCT3, B2RB37, |
| UniProt Related Accession: | Q96GG9 |
| Molecular Weight: | 30,124 Da |
| NCBI Full Name: | DCN1-like protein 1 isoform 2 |
| NCBI Synonym Full Names: | defective in cullin neddylation 1 domain containing 1 |
| NCBI Official Symbol: | DCUN1D1�� |
| NCBI Official Synonym Symbols: | RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1�� |
| NCBI Protein Information: | DCN1-like protein 1 |
| UniProt Protein Name: | DCN1-like protein 1 |
| UniProt Synonym Protein Names: | DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene |
| Protein Family: | DCN1-like protein |
| UniProt Gene Name: | DCUN1D1�� |
| UniProt Entry Name: | DCNL1_HUMAN |
