Description
| Product Name: | Human DBI Recombinant Protein |
| Product Code: | RPPB3327 |
| Size: | 25µg |
| Species: | Human |
| Target: | DBI |
| Synonyms: | ACBP, ACBD1, CCK-RP, EP, DBI, EP, MGC70414, Acyl-CoA-binding protein, GABA receptor modulator. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | DBI Human solution containing 20mM Tris-HCl pH-8, 0.1M NaCl & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI |
DBI, also known as Acyl-CoA-binding protein isoform 2, is a�binding inhibitor, which is regulated by hormones. DBI participates in lipid metabolism and in the displacement of beta-carbolines & benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. Moreover, during adipocyte differentiation the expression of DBI is significantly induced. DBI preforms as an acyl-CoA pool former and regulates LCFA (long-chain fatty acids) metabolism in peripheral tissues.
DBI Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 107 amino acids (1-87a.a.) and having a molecular mass of 12.2kDa. DBI protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 2q12-q21 Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum Molecular Function:protein dimerization activity; benzodiazepine receptor binding; lipid binding Biological Process: learning and/or memory; protein palmitoylation; triacylglycerol metabolic process; behavioral fear response; hair follicle development; transport; lateral ventricle development |
| UniProt Code: | P07108 |
| NCBI GenInfo Identifier: | 118276 |
| NCBI Gene ID: | 1622 |
| NCBI Accession: | P07108.2 |
| Molecular Weight: | 12kDa |
| NCBI Full Name: | Acyl-CoA-binding protein |
| UniProt Protein Name: | Acyl-CoA-binding protein |
| UniProt Synonym Protein Names: | Diazepam-binding inhibitor; DBI; Endozepine; EP |
| Protein Family: | DBIRD complex |
| UniProt Gene Name: | DBI�� |
| UniProt Entry Name: | ACBP_HUMAN |
