Description
| Product Name: | Human CTHRC1 Recombinant Protein |
| Product Code: | RPPB3307 |
| Size: | 10µg |
| Species: | Human |
| Target: | CTHRC1 |
| Synonyms: | Collagen triple helix repeat-containing protein 1 isoform 1, CTHRC1, Protein NMTC1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CTHRC1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPSEIPKGK QKAQLRQREV VDLYNGMCLQ GPAGVPGRDG SPGANGIPGT PGIPGRDGFK GEKGECLRES FEESWTPNYK QCSWSSLNYG IDLGKIAECT FTKMRSNSAL RVLFSGSLRL KCRNACCQRW YFTFNGAECS GPLPIEAIIY LDQGSPEMNS TINIHRTSSV EGLCEGIGAG LVDVAIWVGT CSDYPKGDAS TGWNSVSRII IEELPKHHHH HH |
Collagen triple helix repeat-containing protein 1 or CTHRC1 acts as a negative regulator of collagen matrix deposition. The protein is secreted from a 28kDa protein which is glycosylated and very conserved from lower chordates to mammals. CTHRC1 is found qualitatively in plasma of healthy human subjects. CTHRC1 plasma levels are also significantly elevated during pregnancy, in diabetes, in inflammatory and infectious conditions, in subjects with acute myeloid leukemia but not in subjects with solid cancers.CTHRC1 is highly connected with calcified tissues and cartilaginous matrix, but not with endothelial cells.
CTHRC1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 222 amino acids (31-243a.a.) and having a molecular mass of 24.1kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). CTHRC1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Code: | Q96CG8 |
| NCBI GenInfo Identifier: | 19923989 |
| NCBI Gene ID: | 115908 |
| NCBI Accession: | NP_612464.1 |
| UniProt Secondary Accession: | Q96CG8,Q6UW91, Q8IX63, |
| UniProt Related Accession: | Q96CG8 |
| Molecular Weight: | 26,224 Da |
| NCBI Full Name: | collagen triple helix repeat-containing protein 1 |
| NCBI Synonym Full Names: | collagen triple helix repeat containing 1 |
| NCBI Official Symbol: | CTHRC1�� |
| NCBI Official Synonym Symbols: | CTHRC1�� |
| NCBI Protein Information: | collagen triple helix repeat-containing protein 1; OTTHUMP00000227821; OTTHUMP00000227823 |
| UniProt Protein Name: | Collagen triple helix repeat-containing protein 1 |
| UniProt Synonym Protein Names: | Protein NMTC1 |
| Protein Family: | Collagen triple helix repeat-containing protein |
| UniProt Gene Name: | CTHRC1�� |
| UniProt Entry Name: | CTHR1_HUMAN |
