Description
| Product Name: | Human CSRP2 Recombinant Protein |
| Product Code: | RPPB3278 |
| Size: | 10µg |
| Species: | Human |
| Target: | CSRP2 |
| Synonyms: | Cysteine and glycine-rich protein 2, Smooth muscle cell LIM protein, LIM domain only 5 smooth muscle, SmLIM, LMO5, CRP2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CSRP2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMPVWGG GNKCGACGRT VYHAEEVQCD GRSFHRCCFL CMVCRKNLDS TTVAIHDEEI YCKSCYGKKY GPKGYGYGQG AGTLNMDRGE RLGIKPESVQ PHRPTTNPNT SKFAQKYGGA EKCSRCGDSV YAAEKIIGAG KPWHKNCFRC AKCGKSLEST TLTEKEGEIY CKGCYAKNFG PKGFGYGQGA GALVHAQ |
CSRP2 belongs to the CSRP family. CSRP2 holds 2 LIM zinc-binding domains that take part in regulatory processes essential for development and cellular differentiation. Additionally, CSRP2 is involved in the development of the embryonic vascular system.
CSRP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 217 amino acids (1-193) and having a molecular mass of 23.5kDa.CSRP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CSRP2: a LIM protein that is differentially regulated and preferentially expressed in aortic smooth muscle cells. Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 12q21.1 Cellular Component: focal adhesion; nucleus Molecular Function:zinc ion binding Biological Process: multicellular organismal development; cell differentiation |
| NCBI Summary: | CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. [provided by RefSeq] |
| UniProt Code: | Q16527 |
| NCBI GenInfo Identifier: | 4503101 |
| NCBI Gene ID: | 1466 |
| NCBI Accession: | NP_001312.1 |
| UniProt Secondary Accession: | Q16527,Q93030, |
| UniProt Related Accession: | Q16527 |
| Molecular Weight: | 20,954 Da |
| NCBI Full Name: | cysteine and glycine-rich protein 2 |
| NCBI Synonym Full Names: | cysteine and glycine-rich protein 2 |
| NCBI Official Symbol: | CSRP2�� |
| NCBI Official Synonym Symbols: | CRP2; LMO5; SmLIM�� |
| NCBI Protein Information: | cysteine and glycine-rich protein 2; LMO-5; cysteine-rich protein 2; LIM domain only protein 5; smooth muscle cell LIM protein; LIM domain only 5, smooth muscle |
| UniProt Protein Name: | Cysteine and glycine-rich protein 2 |
| UniProt Synonym Protein Names: | Cysteine-rich protein 2; CRP2; LIM domain only protein 5; LMO-5; Smooth muscle cell LIM protein |
| Protein Family: | Cysteine and glycine-rich protein |
| UniProt Gene Name: | CSRP2�� |
| UniProt Entry Name: | CSRP2_HUMAN |
