Description
| Product Name: | Human CRP (19-224 a.a) Recombinant Protein |
| Product Code: | RPPB3263 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRP (19-224 a.a) |
| Synonyms: | C-reactive protein, CRP, PTX1, MGC88244, MGC149895. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CRP protein solution (1mg/ml) containing 20mM Tris-HCl, pH8.0, 2M Urea and 20% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MQTDMSRKAF VFPKESDTSY VSLKAPLTKP LKAFTVCLHF YTELSSTRGY SIFSYATKRQ DNEILIFWSK DIGYSFTVGG SEILFEVPEV TVAPVHICTS WESASGIVEF WVDGKPRVRK SLKKGYTVGA EASIILGQEQ DSFGGNFEGS QSLVGDIGNV NMWDFVLSPD EINTIYLGGP FSPNVLNWRA LKYEVQGEVF TKPQLWP |
CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.
CRP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids (19-224 a.a.) and having a molecular mass of 23.2kDa.CRP is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
| UniProt Protein Details: | Cofactor: Binds 2 calcium ions per subunit. Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular location: Secreted. Tissue specificity: Found in plasma. Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6. Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain. Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15 |
| NCBI Summary: | The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq] |
| UniProt Code: | P02741 |
| NCBI GenInfo Identifier: | 117486 |
| NCBI Gene ID: | 1401 |
| NCBI Accession: | P02741.1 |
| UniProt Secondary Accession: | P02741,Q08AK3, Q8WW75, A8K078, D3DVD9, D3DVE0, |
| UniProt Related Accession: | P02741,Q5VVP7 |
| Molecular Weight: | 25,039 Da |
| NCBI Full Name: | C-reactive protein |
| NCBI Synonym Full Names: | C-reactive protein, pentraxin-related |
| NCBI Official Symbol: | CRP�� |
| NCBI Official Synonym Symbols: | PTX1; MGC88244; MGC149895�� |
| NCBI Protein Information: | C-reactive protein; pentraxin 1; OTTHUMP00000033307 |
| UniProt Protein Name: | C-reactive protein |
| Protein Family: | Cryparin |
| UniProt Gene Name: | CRP�� |
| UniProt Entry Name: | CRP_HUMAN |
