Description
| Product Name: | Human CRHBP (22-322) Recombinant Protein |
| Product Code: | RPPB1270 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRHBP (22-322) |
| Synonyms: | Corticotropin releasing hormone binding protein, CRF-BP, CRH-BP, CRF-binding protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CRHBP protein (1mg/ml) contains 10% glycerol, 0.4M urea and 20mM Tris-HCl buffer (pH 8.0). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSESRYLEL REAADYDPFL LFSANLKREL AGEQPYRRAL RCLDMLSLQG QFTFTADRPQ LHCAAFFISE PEEFITIHYD QVSIDCQGGD FLKVFDGWIL KGEKFPSSQD HPLPSAERYI DFCESGLSRR SIRSSQNVAM IFFRVHEPGN GFTLTIKTDP NLFPCNVISQ TPNGKFTLVV PHQHRNCSFS IIYPVVIKIS DLTLGHVNGL QLKKSSAGCE GIGDFVELLG GTGLDPSKMT PLADLCYPFH GPAQMKVGCD NTVVRMVSSG KHVNRVTFEY RQLEPYELEN PNGNSIGEFC LSGL |
Corticotropin Releasing Hormone Binding Protein or CRHBP is a hormone that stimulates the preopiomelanocortin-derived peptides secretion & synthesis. In general, the levels of CRHBP in the human plasma are relatively low. There are times when we can find high levels of the hormone, mainly in pregnancy, after parturition the levels drop back, the high levels are thought to be derived from the placenta. CRH-binding protein can be found in the plasma, this protein inactivates CRH, in order to avoid inappropriate pituitary-adrenal stimulation during gestation.
CRHBP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 324 amino acids (22-322 a.a) and having a molecular mass of 36.1kDa.CRHBP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Inhibitor; Secreted Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: dendrite; endoplasmic reticulum; extracellular space; Golgi apparatus; intracellular; microtubule; multivesicular body; nerve terminal; nucleus; perikaryon; secretory granule Molecular Function:corticotropin-releasing hormone binding; peptide binding; protein binding Biological Process: behavioral response to ethanol; cellular response to stress; female pregnancy; hormone-mediated signaling; inflammatory response; learning and/or memory; negative regulation of adrenocorticotropic hormone secretion; regulated secretory pathway; regulation of adrenocorticotropin hormone secretion; signal transduction; synaptic transmission, dopaminergic |
| NCBI Summary: | Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24387 |
| NCBI GenInfo Identifier: | 544099 |
| NCBI Gene ID: | 1393 |
| NCBI Accession: | P24387.2 |
| UniProt Secondary Accession: | P24387,Q53F32, Q6FHT5, |
| UniProt Related Accession: | P24387 |
| Molecular Weight: | 36,144 Da |
| NCBI Full Name: | Corticotropin-releasing factor-binding protein |
| NCBI Synonym Full Names: | corticotropin releasing hormone binding protein |
| NCBI Official Symbol: | CRHBP�� |
| NCBI Official Synonym Symbols: | CRFBP; CRF-BP�� |
| NCBI Protein Information: | corticotropin-releasing factor-binding protein |
| UniProt Protein Name: | Corticotropin-releasing factor-binding protein |
| UniProt Synonym Protein Names: | Corticotropin-releasing hormone-binding protein; CRH-BP |
| Protein Family: | Corticotropin-releasing factor-binding protein |
| UniProt Gene Name: | CRHBP�� |
| UniProt Entry Name: | CRHBP_HUMAN |
