Description
| Product Name: | Human CRABP1 Recombinant Protein |
| Product Code: | RPPB3244 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRABP1 |
| Synonyms: | Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I, CRABP1, RBP5, CRABP, CRABPI. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CRABP1 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by�SDS-PAGE. |
| Amino Acid Sequence: | MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE |
CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though, CRABP1 is structurally similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore, frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.
CRABP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 137 amino acids and having a molecular mass of 15.5kDa. The CRABP1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRABP1: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: cytosol Molecular Function:protein binding; retinoid binding Biological Process: multicellular organismal development; signal transduction |
| NCBI Summary: | This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29762 |
| NCBI GenInfo Identifier: | 266904 |
| NCBI Gene ID: | 1381 |
| NCBI Accession: | P29762.2 |
| UniProt Secondary Accession: | P29762,Q6IAY7, Q8WTV5, |
| UniProt Related Accession: | P29762 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Cellular retinoic acid-binding protein 1 |
| NCBI Synonym Full Names: | cellular retinoic acid binding protein 1 |
| NCBI Official Symbol: | CRABP1�� |
| NCBI Official Synonym Symbols: | RBP5; CRABP; CRABPI; CRABP-I�� |
| NCBI Protein Information: | cellular retinoic acid-binding protein 1 |
| UniProt Protein Name: | Cellular retinoic acid-binding protein 1 |
| UniProt Synonym Protein Names: | Cellular retinoic acid-binding protein I; CRABP-I |
| Protein Family: | Cellular retinoic acid-binding protein |
| UniProt Gene Name: | CRABP1�� |
