Description
| Product Name: | Human CHCHD7 Recombinant Protein |
| Product Code: | RPPB3165 |
| Size: | 10µg |
| Species: | Human |
| Target: | CHCHD7 |
| Synonyms: | Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, Coiled-Coil-Helix-Coiled-Coil-HelixDomain-Containing Protein 7, COX23 Cytochrome C Oxidase Assembly Homolog (S.Cerevisiae), COX23 Cytochrome C Oxidase Assembly Homolog , COX23, Coiled-coil-helix-coiled-coil-helixdomain-containing protein 7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CHCHD7 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMHQTRTG KKTVRMPSVT QRLRDPDINP CLSESDASTR CLDENNYDRERCSTYFLRYK NCRRFWNSIV MQRRKNGVKP FMPTAAERDE ILRAVGNMPY |
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, also known asCHCHD7 is a newly recognized member of a multifamily of proteins which containsa conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. Thebiological function of CHCHD7 is unknown and the gene has up till now not beenconnected with neoplasia. In addition, CHCHD7 & PLAG1 are locatedhead-to-head about 500 bp apart in 8q12. Molecular analyses of twenty seventumors exposed CHCHD7-PLAG1 fusions in three tumors, two of them had t(6;8) andt(8;15) translocations as a singular anomalies and one a normal karyotype.
CHCHD7 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 120 amino acids (1-97 a.a) andhaving a molecular mass of 13.9kDa.CHCHD7 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CHCHD7: A chromosomal aberration involving CHCHD7 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(6;8)(p21.3-22;q13) with PLAG1. Belongs to the CHCHD7 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8q11.23 Cellular Component: mitochondrial intermembrane space |
| UniProt Code: | Q9BUK0 |
| NCBI GenInfo Identifier: | 62510507 |
| NCBI Gene ID: | 79145 |
| NCBI Accession: | Q9BUK0.1 |
| UniProt Secondary Accession: | Q9BUK0,Q7Z588, A8K223, E9PBH3, J3KNE9, |
| UniProt Related Accession: | Q9BUK0 |
| Molecular Weight: | 85 |
| NCBI Full Name: | Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 |
| NCBI Synonym Full Names: | coiled-coil-helix-coiled-coil-helix domain containing 7 |
| NCBI Official Symbol: | CHCHD7�� |
| NCBI Official Synonym Symbols: | COX23�� |
| NCBI Protein Information: | coiled-coil-helix-coiled-coil-helix domain-containing protein 7; COX23 cytochrome c oxidase assembly homolog |
| UniProt Protein Name: | Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 |
| Protein Family: | Coiled-coil-helix-coiled-coil-helix domain-containing protein |
| UniProt Gene Name: | CHCHD7�� |
| UniProt Entry Name: | CHCH7_HUMAN |
