Description
| Product Name: | Human CEACAM6 Recombinant Protein |
| Product Code: | RPPB3137 |
| Size: | 10µg |
| Species: | Human |
| Target: | CEACAM6 |
| Synonyms: | Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CEACAM6, CD66c, CEAL, NCA, Non-specific crossreacting antigen, Normal cross-reacting antigen, CD_antigen: CD66c, NCA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CEACAM6 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | ADPEFKLTIE STPFNVAEGK EVLLLAHNLP QNRIGYSWYK GERVDGNSLI VGYVIGTQQA TPGPAYSGRE TIYPNASLLI QNVTQNDTGF YTLQVIKSDL VNEEATGQFH VYPELPKPSI SSNNSNPVED KDAVAFTCEP EVQNTTYLWW VNGQSLPVSP RLQLSNGNMT LTLLSVKRND AGSYECEIQN PASANRSDPV TLNVLYGPDV PTISPSKANY RPGENLNLSC HAASNPPAQY SWFINGTFQQ STQELFIPNI TVNNSGSYMC QAHNSATGLN RTTVTMITVS GHHHHHH |
CarcinoembryonicAntigen-Related Cell Adhesion Molecule 6 (CEACAM6) is a part of the humancarcino-embryonic antigen (CEA) family. CEACAM6 belongs to the glycosylphosphatidylinositol-linkedimmunoglobulin superfamily which is involved in various human cancers. CEACAM6is linked to the progression of pancreatic cancer.
CEACAM6 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 297 amino acids (35-320) and having a molecular mass of 32.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).CEACAM6 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CEACAM6: Belongs to the immunoglobulin superfamily. CEA family |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: cell-cell signaling; leukocyte migration; signal transduction |
| NCBI Summary: | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014] |
| UniProt Code: | P40199 |
| NCBI GenInfo Identifier: | 296439410 |
| NCBI Gene ID: | 4680 |
| NCBI Accession: | P40199.3 |
| UniProt Secondary Accession: | P40199,Q13774, Q14920, Q53XP7, |
| UniProt Related Accession: | P40199 |
| Molecular Weight: | 37,195 Da |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 6 |
| NCBI Official Symbol: | CEACAM6�� |
| NCBI Official Synonym Symbols: | NCA; CEAL; CD66c�� |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 6 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| UniProt Synonym Protein Names: | Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c |
| Protein Family: | Carcinoembryonic antigen-related cell adhesion molecule |
| UniProt Gene Name: | CEACAM6�� |
| UniProt Entry Name: | CEAM6_HUMAN |
