Description
| Product Name: | Human CDC26 Recombinant Protein |
| Product Code: | RPPB3117 |
| Size: | 20µg |
| Species: | Human |
| Target: | CDC26 |
| Synonyms: | Anaphase-promoting complex subunit CDC26, Anaphase-promoting complex subunit 12, APC12, Cell division cycle protein 26 homolog, CDC26, ANAPC12, C9orf17. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CDC26 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM INDRIGYKPQ PKPNNRSSQF GSLEF |
CDC26 is a member of the CDC26 family which arranges progression via mitosis by enhancing cell-cycle regulators with ubiquitin chains. CDC26 is a component of the anaphase promoting complex/cyclosome (APC/C), which is a cell cycle-regulated E3 ubiquitin ligase which directs progression through mitosis and the G1 phase of the cell cycle. The APC/C complex operates by mediating ubiquitination and subsequent degradation of target proteins.
CDC26 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 105 amino acids (1-85 a.a) and having a molecular mass of 11.9kDa.CDC26 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CDC26: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the CDC26 family.Chromosomal Location of Human Ortholog: 9q32Cellular Component: nucleoplasm; anaphase-promoting complex; cytosolMolecular Function: protein bindingBiological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHZ8 |
| NCBI GenInfo Identifier: | 21281671 |
| NCBI Gene ID: | 246184 |
| NCBI Accession: | NP_644815.1 |
| UniProt Secondary Accession: | Q8NHZ8 |
| UniProt Related Accession: | Q8NHZ8 |
| Molecular Weight: | 9,777 Da |
| NCBI Full Name: | anaphase-promoting complex subunit CDC26 |
| NCBI Synonym Full Names: | cell division cycle 26 |
| NCBI Official Symbol: | CDC26�� |
| NCBI Official Synonym Symbols: | APC12; ANAPC12; C9orf17�� |
| NCBI Protein Information: | anaphase-promoting complex subunit CDC26; cell division cycle 26 homolog; anaphase-promoting complex subunit 12; cell division cycle protein 26 homolog; CDC26 subunit of anaphase promoting complex |
| UniProt Protein Name: | Anaphase-promoting complex subunit CDC26 |
| UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homolog |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | CDC26�� |
| UniProt Entry Name: | CDC26_HUMAN |
