Description
| Product Name: | Human CD74 Recombinant Protein |
| Product Code: | RPPB5875 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD74 |
| Synonyms: | DHLAG, HLADG, Ia-GAMMA, li, HLA-DR antigens-associatedinvariant chain, p33, Ia antigen-associated invariant chain, HLA class IIhistocompatibility antigen gamma chain, CD74, Gamma Chain Of Class II Antigens,MHC HLA-DR Gamma Chain. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD74 protein solution (0.5mg/ml) contains phosphatebuffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QQQGRLDKLT VTSQNLQLEN LRMKLPKPPK PVSKMRMATP LLMQALPMGALPQGPMQNAT KYGNMTEDHV MHLLQNADPL KVYPPLKGSF PENLRHLKNT METIDWKVFE SWMHHWLLFEMSRHSLEQKP TDAPPKESLE LEDPSSGLGV TKQDLGPVPM HHHHHH |
CD74 (HLA class II histocompatibility antigen gamma chain isoform b), is a transmembrane protein (on antigen presenting cells) which is the invariant chain that chaperones MHC class IIdimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and Blymphocyte lineages. CD74 upregulated in several cancers and is also expressed by non immune cells during inflammation. Diseases related with CD74 include thymic epithelial neoplasm and gastroduodenitis. Among its related super-pathways are Immune System and Immune response Antigen presentation by MHC class II. In addition CD74 functions as cell surface receptor for the cytokine MIF.�
CD74 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 166 amino acids (73-232a.a.) andhaving a molecular mass of 19.05kDa (Molecular size on SDS-PAGE will appear atapproximately 18-28kDa). CD74 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. |
| NCBI Summary: | The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P04233 |
| NCBI GenInfo Identifier: | 20178292 |
| NCBI Gene ID: | 972 |
| NCBI Accession: | P04233.3 |
| UniProt Secondary Accession: | P04233,Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6, A8K7R1 B4DNE8, D3DQG3, D3DQG4, |
| UniProt Related Accession: | P04233 |
| Molecular Weight: | |
| NCBI Full Name: | HLA class II histocompatibility antigen gamma chain |
| NCBI Synonym Full Names: | CD74 molecule |
| NCBI Official Symbol: | CD74�� |
| NCBI Official Synonym Symbols: | II; DHLAG; HLADG; Ia-GAMMA�� |
| NCBI Protein Information: | HLA class II histocompatibility antigen gamma chain |
| UniProt Protein Name: | HLA class II histocompatibility antigen gamma chain |
| UniProt Synonym Protein Names: | HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD_antigen: CD74 |
| Protein Family: | H-2 class II histocompatibility antigen |
| UniProt Gene Name: | CD74�� |
| UniProt Entry Name: | HG2A_HUMAN |
