Description
| Product Name: | Human CD23 Recombinant Protein |
| Product Code: | RPPB5872 |
| Size: | 5µg |
| Species: | Human |
| Target: | CD23 |
| Synonyms: | Low affinity immunoglobulin epsilon Fc receptor isoform a, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, C-type lectin domain family 4 member J, Immunoglobulin E-binding factor, Lymphocyte IgE receptor. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | FCER2 protein solution (0.25mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPDTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLRNLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPTPSAPLHSHHH HHH |
FCER2, or Fc epsilon RII, is a receptor for IgE with low affinity, which is critical to regulation of IgE levels. IgE is an antibody isotype that attached to allergy and resistance to parasites. FCER2 is a C-type lectin, contrary to many of the receptors for antibodies. FCER2 is located on activated macrophages, mature B cells, follicular dendritic cells, platelets and eosinophils.
FCER2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 283 amino acids (48-321a.a.) and having a molecular mass of 32.0kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).FCER2 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). |
| NCBI Summary: | The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P06734 |
| NCBI GenInfo Identifier: | 119862 |
| NCBI Gene ID: | 2208 |
| NCBI Accession: | P06734.1 |
| UniProt Related Accession: | P06734 |
| Molecular Weight: | |
| NCBI Full Name: | Low affinity immunoglobulin epsilon Fc receptor |
| NCBI Synonym Full Names: | Fc fragment of IgE receptor II |
| NCBI Official Symbol: | FCER2�� |
| NCBI Official Synonym Symbols: | CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2�� |
| NCBI Protein Information: | low affinity immunoglobulin epsilon Fc receptor |
| UniProt Protein Name: | Low affinity immunoglobulin epsilon Fc receptor |
| UniProt Synonym Protein Names: | BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD_antigen: CD23Cleaved into the following 2 chains:Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form |
| UniProt Gene Name: | FCER2�� |
| UniProt Entry Name: | FCER2_HUMAN |
