Description
system_update_altDatasheet
| Product name | Human CCR9 full length protein-synthetic nanodisc |
| Size: | 10ug |
| Product SKU: | HDFP042 |
| Product Category | Full Length Transmembrane Proteins |
| Target: | CCR9 |
| Uniprot: | P51686 |
| Description: | Human CCR9 full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length CCR9 protein has a MW of 42.0 kDa |
| Protein Family: | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways: | Chemokine signaling pathway, Cytokine-cytokine receptor interaction |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Synonyms: | CC-CKR-9; CDw199; GPR-9-6; GPR28 |
| Expression System: | HEK293 |
| Formulation: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Background: | The protein is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. |
| Delivery: | In Stock |
| Usage | Research use only |
