Description
| Product Name: | Human CAB39 Recombinant Protein |
| Product Code: | RPPB2956 |
| Size: | 10µg |
| Species: | Human |
| Target: | CAB39 |
| Synonyms: | MO25, CAB-39, CGI-66, FLJ22682, Calcium Binding Protein 39. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The CAB39 solution (0.5mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYISKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A |
CAB39 protein and STE20-related adaptor-alpha pseudo kinase, form a regulatory complex that is able of stimulating the activity of the LKB1 tumor suppressor protein kinase. CAB39 takes part as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.
CAB39 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 361 amino acids (1-341 a.a.) and having a molecular mass of 42 kDa. The CAB39 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CAB39: a adaptor protein that, together with STRAD-alpha, forms a regulatory complex capable of stimulating the activity of LKB1. Interacts with Mst4, which plays an essential role in brush border formation in intestinal epithelial cells. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: cytosol Molecular Function:protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; kinase binding; protein kinase activator activity Biological Process: protein heterooligomerization; activation of protein kinase activity; insulin receptor signaling pathway; cell cycle arrest; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation |
| UniProt Code: | Q9Y376 |
| NCBI GenInfo Identifier: | 195927020 |
| NCBI Gene ID: | 51719 |
| NCBI Accession: | NP_001124321.1 |
| UniProt Secondary Accession: | Q9Y376,A8K8L7, |
| UniProt Related Accession: | Q9Y376 |
| Molecular Weight: | 39,869 Da |
| NCBI Full Name: | calcium-binding protein 39 |
| NCBI Synonym Full Names: | calcium binding protein 39 |
| NCBI Official Symbol: | CAB39�� |
| NCBI Official Synonym Symbols: | MO25; CGI-66�� |
| NCBI Protein Information: | calcium-binding protein 39; MO25alpha |
| UniProt Protein Name: | Calcium-binding protein 39 |
| UniProt Synonym Protein Names: | MO25alpha; Protein Mo25 |
| Protein Family: | Mo25-like protein |
| UniProt Gene Name: | CAB39�� |
| UniProt Entry Name: | CAB39_HUMAN |
