Description
| Product Name: | Human BLVRB Recombinant Protein |
| Product Code: | RPPB1449 |
| Size: | 50µg |
| Species: | Human |
| Target: | BLVRB |
| Synonyms: | FLR, BVRB, SDR43U1, MGC117413, BLVRB, Flavin reductase, FR, NADPH-dependent diaphorase, NADPH-flavin reductase, Biliverdin reductase B, BVR-B, Biliverdin-IX beta-reductase, Green heme-binding protein, GHBP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein contains 20mM Tris-HCl buffer pH 8.5, 10% glycerol, and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAVKKIAIFG ATGQTGLTTL AQAVQAGYEV TVLVRDSSRL PSEGPRPAHV VVGDVLQAAD VDKTVAGQDA VIVLLGTRND LSPTTVMSEG ARNIVAAMKA HGVDKVVACT SAFLLWDPTK VPPRLQAVTD DHIRMHKVLR ESGLKYVAVM PPHIGDQPLT GAYTVTLDGR GPSRVISKHD LGHFMLRCLT TDEYDGHSTY PSHQYQ |
BLVRB (EC 1.3.1.24) catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. BLVRB is involved in protecting cells from oxidative damage or in regulating iron metabolism. BLVRB converts biliverdin to bilirubin in the liver, converting a double-bond between the second and third pyrrole ring into a single-bond. BLVRB plays a role as in human erythrocytic heme catabolic pathway and most mammalian species. Biliverdin reductase is abundantly expressed in kidney, spleen, liver and brain as well as at lower levels in the thymus and minimal levels being detected in testis.
BLVRB Human Recombinant amino produced in E.Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids having a molecular mass of 22.1 kDa.The BLVRB is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BLVRB: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. |
| UniProt Protein Details: | Protein type:EC 1.5.1.30; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; EC 1.3.1.24 Chromosomal Location of Human Ortholog: 19q13.1-q13.2 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol Molecular Function:flavin reductase activity; biliverdin reductase activity Biological Process: heme catabolic process; porphyrin metabolic process |
| NCBI Summary: | The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009] |
| UniProt Code: | P30043 |
| NCBI GenInfo Identifier: | 1706870 |
| NCBI Gene ID: | 645 |
| NCBI Accession: | P30043.3 |
| UniProt Secondary Accession: | P30043,P32078, P53005, Q32LZ2, A6NKD8, B2R5C6, |
| UniProt Related Accession: | P30043 |
| Molecular Weight: | 206 |
| NCBI Full Name: | Flavin reductase (NADPH) |
| NCBI Synonym Full Names: | biliverdin reductase B |
| NCBI Official Symbol: | BLVRB�� |
| NCBI Official Synonym Symbols: | FLR; BVRB; SDR43U1; HEL-S-10�� |
| NCBI Protein Information: | flavin reductase (NADPH); flavin reductase (NADPH); FR; GHBP; BVR-B; NADPH-flavin reductase; NADPH-dependent diaphorase; green heme-binding protein; biliverdin-IX beta-reductase; epididymis secretory protein Li 10; biliverdin reductase B (flavin reductase (NADPH)); short chain dehydrogenase/reductase family 43U, member 1 |
| UniProt Protein Name: | Flavin reductase (NADPH) |
| UniProt Synonym Protein Names: | Biliverdin reductase B (EC:1.3.1.24); BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR |
| UniProt Gene Name: | BLVRB�� |
| UniProt Entry Name: | BLVRB_HUMAN |
