Description
| Product Name: | Human BCL7A Recombinant Protein |
| Product Code: | RPPB2876 |
| Size: | 10µg |
| Species: | Human |
| Target: | BCL7A |
| Synonyms: | B-cell CLL/lymphoma 7 protein family member A, BCL7A, BCL7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | BCL7A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol, 1mM DTT and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSGRSVR AETRSRAKDD IKRVMAAIEK VRKWEKKWVT VGDTSLRIYK WVPVTEPKVD DKNKNKKKGK DEKCGSEVTT PENSSSPGMM DMHDDNSNQS SIADASPIKQ ENSSNSSPAP EPNSAVPSDG TEAKVDEAQA DGKEHPGAED ASDEQNSQSS MEHSMNSSEK VDRQPSGDSG LAAETSAISQ DLEGVPPSKK MKLEASQQNS EEM |
B-cell CLL/lymphoma 7A (BCL7A) is a member of the BCL7 family. BCL7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. Thru gene translocation, the N-terminal region of the BCL7A gene is disrupted, which is assumed to be connected to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal portion involved in the translocation includes the region which shares a compelling sequence similarity with those of BCL7B and BCL7C. Chromosomal anomalies involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma.
BCL7A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (1-210 a.a.) and having a molecular mass of 25.2kDa (Molecular size on SDS-PAGE will appear higher).BCL7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Bcl-7A: Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. Belongs to the BCL7 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Actin-bindingChromosomal Location of Human Ortholog: 12q24.13Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q4VC05 |
| NCBI GenInfo Identifier: | 74754614 |
| NCBI Gene ID: | 605 |
| NCBI Accession: | Q4VC05.1 |
| UniProt Secondary Accession: | Q4VC05,Q13843, Q14CT7, B4DJN6, B7ZB21 |
| UniProt Related Accession: | Q4VC05 |
| Molecular Weight: | 25,029 Da |
| NCBI Full Name: | B-cell CLL/lymphoma 7 protein family member A |
| NCBI Synonym Full Names: | BCL tumor suppressor 7A |
| NCBI Official Symbol: | BCL7A�� |
| NCBI Official Synonym Symbols: | BCL7�� |
| NCBI Protein Information: | B-cell CLL/lymphoma 7 protein family member A |
| UniProt Protein Name: | B-cell CLL/lymphoma 7 protein family member A |
| UniProt Synonym Protein Names: | |
| Protein Family: | B-cell CLL/lymphoma 7 protein family |
| UniProt Gene Name: | BCL7A�� |
| UniProt Entry Name: | BCL7A_HUMAN |
