Description
| Product Name: | Human ATOX1 Recombinant Protein |
| Product Code: | RPPB2816 |
| Size: | 20µg |
| Species: | Human |
| Target: | ATOX1 |
| Synonyms: | Antioxidant protein 1, ATX1, HAH1, Copper transport protein ATOX1, Metal transport protein ATX1, ATOX1, MGC138453, MGC138455. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | ATOX1 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK TVSYLGLE |
ATOX1 is a metal transport protein that is part of the ATX1 family. ATOX1 is a copper chaperone that takes part in cellular antioxidant defense and can bind and deliver cytosolic copper to the copper ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. ATOX1 plays a role as an antioxidant against superoxide and hydrogen peroxide, and consequently, takes an important part in cancer carcinogenesis. Because of ATOX1 cytogenetic location, the gene can be a good a candidate gene for 5q-syndrome.
ATOX1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids (1-68 a.a.) and having a molecular mass of 9.5kDa. ATOX1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATOX1: Could bind and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Belongs to the ATX1 family. |
| UniProt Protein Details: | Protein type:Carrier Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytosol Molecular Function:metallochaperone activity; copper ion transmembrane transporter activity; copper ion binding; copper chaperone activity; copper-dependent protein binding Biological Process: response to reactive oxygen species; cellular copper ion homeostasis; response to oxidative stress; copper ion transport; intracellular copper ion transport |
| NCBI Summary: | This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00244 |
| NCBI GenInfo Identifier: | 7531045 |
| NCBI Gene ID: | 475 |
| NCBI Accession: | O00244.1 |
| UniProt Secondary Accession: | O00244,Q2M1R6, Q56AP3, A8KAJ8, D3DQI2, |
| UniProt Related Accession: | O00244 |
| Molecular Weight: | 68 |
| NCBI Full Name: | Copper transport protein ATOX1 |
| NCBI Synonym Full Names: | antioxidant 1 copper chaperone |
| NCBI Official Symbol: | ATOX1�� |
| NCBI Official Synonym Symbols: | ATX1; HAH1�� |
| NCBI Protein Information: | copper transport protein ATOX1; metal transport protein ATX1; ATX1 antioxidant protein 1 homolog |
| UniProt Protein Name: | Copper transport protein ATOX1 |
| UniProt Synonym Protein Names: | Metal transport protein ATX1 |
| Protein Family: | Copper transport protein |
| UniProt Gene Name: | ATOX1�� |
| UniProt Entry Name: | ATOX1_HUMAN |
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