Description
| Product Name: | Human ASB8 Recombinant Protein |
| Product Code: | RPPB2802 |
| Size: | 10µg |
| Species: | Human |
| Target: | ASB8 |
| Synonyms: | Ankyrin Repeat And SOCS Box Containing 8, ASB-8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The ASB8 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSSMWY IMQSIQSKYS LSERLIRTIA AIRSFPHDNV EDLIRGGADV NCTHGTLKPL HCACMVSDAD CVELLLEKGA EVNALDGYNR TALHYAAEKD EACVEVLLEY GANPNALDGN RDTPLHWAAF KNNAECVRAL LESGASVNAL DYNNDTPLSW AAMKGNLESV SILLDYGAEV RVINLIGQTP ISRLVALLVR GLGTEKEDSC FELLHRAVGH FELRKNGTMP REVARDPQLC EKLTVLCSAP GTLKTLARYA VRRSLGLQYL PDAVKGLPLP ASLKEYLLLL E |
ASB8 is a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex that facilitates the ubiquitination and consequent proteasomal degradation of objective proteins.
ASB8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 311 amino acids (1-288) and having a molecular mass of 34.0kDa.ASB8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ASB8: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.Chromosomal Location of Human Ortholog: 12q13.11Cellular Component: cytoplasmBiological Process: protein ubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H765 |
| NCBI GenInfo Identifier: | 13129098 |
| NCBI Gene ID: | 140461 |
| NCBI Accession: | NP_077000 |
| UniProt Secondary Accession: | Q9H765,Q547Q2, A8K1P2 |
| UniProt Related Accession: | Q9H765 |
| Molecular Weight: | 34.0 kDa (311aa) confirmed by MALDI-TOF |
| NCBI Full Name: | ankyrin repeat and SOCS box protein 8 isoform a |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 8 |
| NCBI Official Symbol: | ASB8�� |
| NCBI Official Synonym Symbols: | PP14212�� |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 8 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB8�� |
| UniProt Entry Name: | ASB8_HUMAN |
