Description
| Product Name: | Human ARPC3 Recombinant Protein |
| Product Code: | RPPB2800 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARPC3 |
| Synonyms: | ARC21, p21-Arc, Actin-related protein 2/3 complex subunit 3, Arp2/3 complex 21 kDa subunit, ARPC3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ARPC3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPAYHSS LMDPDTKLIG NMALLPIRSQ FKGPAPRETK DTDIVDEAIY YFKANVFFKN YEIKNEADRT LIYITLYISE CLKKLQKCNS KSQGEKEMYT LGITNFPIPG EPGFPLNAIY AKPANKQEDE VMRAYLQQLR QETGLRLCEK VFDPQNDKPS KWWTCFVKRQ FMNKSLSGPG Q |
Actin-related protein 2/3 complex subunit 3 (ARPC3) which Belongs to the ARPC3 family is one of 7 subunits of the human Arp2/3 protein complex. The Arp2/3 complex is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. ARPC3 which is localized to the cytoplasm and cytoskeleton, interacts with p20-ARC and takes part in the structural integrity of the protein complex.
ARPC3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 201 amino acids (1-178 a.a) and having a molecular mass of 22.9kDa. ARPC3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARPC3: one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: Arp2/3 protein complex; focal adhesion; membrane; lamellipodium; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility |
| NCBI Summary: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] |
| UniProt Code: | O15145 |
| NCBI GenInfo Identifier: | 3121765 |
| NCBI Gene ID: | 10094 |
| NCBI Accession: | O15145.3 |
| UniProt Secondary Accession: | O15145,O00554, |
| UniProt Related Accession: | O15145 |
| Molecular Weight: | 178 |
| NCBI Full Name: | Actin-related protein 2/3 complex subunit 3 |
| NCBI Synonym Full Names: | actin related protein 2/3 complex, subunit 3, 21kDa |
| NCBI Official Symbol: | ARPC3�� |
| NCBI Official Synonym Symbols: | ARC21; p21-Arc�� |
| NCBI Protein Information: | actin-related protein 2/3 complex subunit 3; arp2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21 |
| UniProt Protein Name: | Actin-related protein 2/3 complex subunit 3 |
| UniProt Synonym Protein Names: | Arp2/3 complex 21 kDa subunit; p21-ARC |
| Protein Family: | Actin-related protein 2/3 complex |
| UniProt Gene Name: | ARPC3�� |
| UniProt Entry Name: | ARPC3_HUMAN |
