Description
| Product Name: | Human ARL2BP Recombinant Protein |
| Product Code: | RPPB2788 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARL2BP |
| Synonyms: | ADP-ribosylation factor-like protein 2-binding protein, ARF-like 2-binding protein, Binder of ARF2 protein 1, ARL2BP, BART, BART1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ARL2BP solution (1 mg/ml) contains 20mM Tris-HCl Buffer (pH 7.5) and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDALEGESFA LSFSSASDAE FDAVVGYLED IIMDDEFQLL QRNFMDKYYL EFEDTEENKL IYTPIFNEYI SLVEKYIEEQ LLQRIPEFNM AAFTTTLQHH KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK SSSLPASQNN LRH |
ARL2BP is an effector of ADP-ribosylation factor-like 2(ARL2) which is vital for nuclear retention of STAT3. The ARL2BP protein binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. Though primarily cytosolic, ARL2BP can enter the mitochondria and bind the adenine nucleotide transporter while bound to ARL2. Accordingly, it may also be involved in mitochondria transport and apoptosis.
ARL2BP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 183 amino acids (1-163) and having a molecular mass of 20.9 kDa.The ARL2BP is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARL2BP: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. Belongs to the ARL2BP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein regulator, misc.; Mitochondrial Chromosomal Location of Human Ortholog: 16q13 Cellular Component: centrosome; cytosol; midbody; mitochondrial intermembrane space; mitochondrial matrix Molecular Function:GTPase regulator activity; protein binding; transcription coactivator activity Biological Process: maintenance of protein localization in nucleus; positive regulation of tyrosine phosphorylation of STAT protein; regulation of insulin secretion; signal transduction Disease: Retinitis Pigmentosa With Or Without Situs Inversus |
| NCBI Summary: | ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2Y0 |
| NCBI GenInfo Identifier: | 6912268 |
| NCBI Gene ID: | 23568 |
| NCBI Accession: | NP_036238.1 |
| UniProt Secondary Accession: | Q9Y2Y0,Q504R0, B3KQJ5, |
| UniProt Related Accession: | Q9Y2Y0 |
| Molecular Weight: | 46.2kD |
| NCBI Full Name: | ADP-ribosylation factor-like protein 2-binding protein |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 2 binding protein |
| NCBI Official Symbol: | ARL2BP�� |
| NCBI Official Synonym Symbols: | BART; RP66; BART1�� |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 2-binding protein |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 2-binding protein |
| UniProt Synonym Protein Names: | Binder of ARF2 protein 1 |
| Protein Family: | ADP-ribosylation factor-like protein |
| UniProt Gene Name: | ARL2BP�� |
