Description
| Product Name: | Human ANXA13 Recombinant Protein |
| Product Code: | RPPB2751 |
| Size: | 20µg |
| Species: | Human |
| Target: | ANXA13 |
| Synonyms: | Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA, ANXA13, ANX13, MGC150460. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The ANXA13 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol, 0.1M NaCl and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR SDTSGDFRKL LVALLH |
Annexin A13 (ANXA13) belongs to the annexin protein family, whose members play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. ANXA13 is believed to be the original originator of the 12 members of vertebrate annexins. ANXA13 expression is decidedly tissue-specific, being expressed only in intestinal and kidney epithelial cells. This expression is linked with a highly differentiated intracellular transport function.
ANXA13 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-316 a.a.) and having a molecular mass of 37.5kDa. The ANXA13 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ANXA13: a calcium/phospholipid-binding protein associated with the cell membrane. ANXA13 is the probable common ancestor of the annexin family of proteins. Annexins all bind to phospholipids in a calcium-dependent manner. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. |
| UniProt Protein Details: | Protein type:Calcium-binding; Lipid-binding Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: nucleoplasm; extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft Molecular Function:calcium-dependent phospholipid binding; phosphatidylserine binding; phosphatidylcholine binding; calcium ion binding Biological Process: negative regulation of Golgi to plasma membrane protein transport; positive regulation of Golgi to plasma membrane protein transport; cell differentiation |
| NCBI Summary: | This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27216 |
| NCBI GenInfo Identifier: | 281185504 |
| NCBI Gene ID: | 312 |
| NCBI Accession: | P27216.3 |
| UniProt Secondary Accession: | P27216,Q9BQR5, |
| UniProt Related Accession: | P27216 |
| Molecular Weight: | 39,744 Da |
| NCBI Full Name: | Annexin A13 |
| NCBI Synonym Full Names: | annexin A13 |
| NCBI Official Symbol: | ANXA13�� |
| NCBI Official Synonym Symbols: | ISA; ANX13�� |
| NCBI Protein Information: | annexin A13; annexin-13; annexin XIII; intestine-specific annexin; annexin, intestine-specific |
| UniProt Protein Name: | Annexin A13 |
| UniProt Synonym Protein Names: | Annexin XIII; Annexin-13; Intestine-specific annexin; ISA |
| Protein Family: | Annexin |
| UniProt Gene Name: | ANXA13�� |
| UniProt Entry Name: | ANX13_HUMAN |
