Description
| Product Name: | Human AMTN Recombinant Protein |
| Product Code: | RPPB2734 |
| Size: | 20µg |
| Species: | Human |
| Target: | AMTN |
| Synonyms: | UNQ689, Amelotin, PRO1329. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | AMTN protein solution (0.5mg/ml) contains mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 20% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSLPQLKPA LGLPPTKLAP DQGTLPNQQQ SNQVFPSLSL IPLTQMLTLG PDLHLLNPAA GMTPGTQTHP LTLGGLNVQQ QLHPHVLPIF VTQLGAQGTI LSSEELPQIF TSLIIHSLFP GGILPTSQAG ANPDVQDGSL PAGGAGVNPA TQGTPAGRLP TPSGTDDDFA VTTPAGIQRS THAIEEATTE SANGIQ |
AMTN is a member of the amelotin family. AMTN is a lately discovered secreted enamel protein. AMTN mainly expressed during the maturation stage of enamel formation. AMTN gathers in a basal lamina-like structure at the interface between ameloblasts and enamel mineral and it co-localizes with one more lately described enamel protein, odontogenic ameloblast- related protein (ODAM(.
AMTN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (17-209 a.a.) and having a molecular mass of 22.2kDa.AMTN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AMTN: Could be a cell adhesion protein involved in the maturation of tooth enamel. Belongs to the amelotin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Extracellular matrix; Secreted; Secreted, signal peptide; Cell adhesionChromosomal Location of Human Ortholog: 4q13.3Cellular Component: basal lamina; intercellular junction; proteinaceous extracellular matrixBiological Process: odontogenesis of dentine-containing teeth |
| UniProt Protein Details: | |
| NCBI Summary: | The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6UX39 |
| NCBI GenInfo Identifier: | 55976710 |
| NCBI Gene ID: | 401138 |
| NCBI Accession: | Q6UX39.1 |
| UniProt Secondary Accession: | Q6UX39,Q0P503, Q0P506 |
| UniProt Related Accession: | Q6UX39 |
| Molecular Weight: | 21,459 Da |
| NCBI Full Name: | Amelotin |
| NCBI Synonym Full Names: | amelotin |
| NCBI Official Symbol: | AMTN�� |
| NCBI Official Synonym Symbols: | UNQ689�� |
| NCBI Protein Information: | amelotin |
| UniProt Protein Name: | Amelotin |
| UniProt Synonym Protein Names: | |
| Protein Family: | Amelotin |
| UniProt Gene Name: | AMTN�� |
| UniProt Entry Name: | AMTN_HUMAN |
