Description
| Product Name: | Human AIDA Recombinant Protein |
| Product Code: | RPPB2722 |
| Size: | 10µg |
| Species: | Human |
| Target: | AIDA |
| Synonyms: | C1orf80, RP11-378J18.7, Axin interactor, dorsalization-associated protein, Axin interaction partner and dorsalization antagonist, AIDA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | AIDA protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.2M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSEVTRS LLQRWGASFR RGADFDSWGQ LVEAIDEYQI LARHLQKEAQ AQHNNSEFTE EQKKTIGKIA TCLELRSAAL QSTQSQEEFK LEDLKKLEPI LKNILTYNKE FPFDVQPVPL RRILAPGEEE NLEFEEDEEE GGAGAGSPDS FPARVPGTLL PRLPSEPGMT LLTIRIEKIG LKDAGQCIDP YITVSVKDLN GIDLTPVQDT PVASRKEDTY VHFNVDIELQ KHVEKLTKGA AIFFEFKHYK PKKRFTSTKC FAFMEMDEIK PGPIVIELYK KPTDFKRKKL QLLTKKPLYL HLHQTLHKE |
Axin interactor, dorsalization-associated (AIDA) operates as a ventralizing factor during embryogenesis. AIDA inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. That in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
AIDA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 329 amino acids (1-306 a.a) and having a molecular mass of 37.4kDa. AIDA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AIDA: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling. Belongs to the AIDA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cell development/differentiationChromosomal Location of Human Ortholog: 1q41Molecular Function: protein bindingBiological Process: dorsal/ventral pattern formation; negative regulation of JNK activity; negative regulation of JNK cascade; regulation of protein homodimerization activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96BJ3 |
| NCBI GenInfo Identifier: | 74751770 |
| NCBI Gene ID: | 64853 |
| NCBI Accession: | Q96BJ3.1 |
| UniProt Secondary Accession: | Q96BJ3,Q49A81, Q5JRA4, Q658P1, Q9H9E8, A8K1F0 |
| UniProt Related Accession: | Q96BJ3 |
| Molecular Weight: | 25,914 Da |
| NCBI Full Name: | Axin interactor, dorsalization-associated protein |
| NCBI Synonym Full Names: | axin interactor, dorsalization associated |
| NCBI Official Symbol: | AIDA�� |
| NCBI Official Synonym Symbols: | C1orf80�� |
| NCBI Protein Information: | axin interactor, dorsalization-associated protein |
| UniProt Protein Name: | Axin interactor, dorsalization-associated protein |
| UniProt Synonym Protein Names: | Axin interaction partner and dorsalization antagonist |
| Protein Family: | AIDA-I autotransporter |
| UniProt Gene Name: | AIDA�� |
| UniProt Entry Name: | AIDA_HUMAN |
