Description
| Product Name: | Human ACY3 Recombinant Protein |
| Product Code: | RPPB5785 |
| Size: | 10µg |
| Species: | Human |
| Target: | ACY3 |
| Synonyms: | Aspartoacylase-2, Acylase III, Aminoacylase-3, ACY-3, Hepatitis C virus core-binding protein 1, HCBP1, ACY3, ASPA2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ACY3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMCSLPVP REPLRRVAVT GGTHGNEMSG VYLARHWLHA PAELQRASFS AVPVLANPAA TSGCRRYVDHDLNRTFTSSF LNSRPTPDDP YEVTRARELN QLLGPKASGQ AFDFVLDLHN TTANMGTCLI AKSSHEVFAM HLCRHLQLQY PELSCQVFLY QRSGEESYNL DSVAKNGLGL ELGPQPQGVL RADIFSRMRT LVATVLDFIE LFNQGTAFPA FEMEAYRPVG VVDFPRTEAG HLAGTVHPQL QDRDFQPLQP GAPIFQMFSG EDLLYEGEST VYPVFINEAA YYEKGVAFVQ TEKFTFTVPA MPALTPAPSP AS |
Aspartoacylase 3 (ACY3) belongs to the Aspartoacylase subfamily. ACY3 has a vital role in deacetylating mercapturic acids in kidney proximal tubules. Aspartoacylase 3 localizes to the cytoplasm of S2 and S3 proximal tubules and also to the apical domain of S1 proximal tubules. In addition, ACY3 protein is expressed at low levels in the stomach, testis, heart, brain, lung and liver, and can function as an HCV (Hepatitis C virus) core binding protein.
ACY3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 342 amino acids (1-319 a.a.) and having a molecular mass of 37.6kDa.ACY3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACY3: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Belongs to the AspA/AstE family. Aspartoacylase subfamily. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - alanine, aspartate and glutamate; Hydrolase; EC 3.5.1.114; Amino Acid Metabolism - histidine Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: cytosol Molecular Function:aminoacylase activity; protein binding Biological Process: xenobiotic metabolic process |
| UniProt Code: | Q96HD9 |
| NCBI GenInfo Identifier: | 34395507 |
| NCBI Gene ID: | 91703 |
| NCBI Accession: | Q96HD9.1 |
| UniProt Related Accession: | Q96HD9 |
| Molecular Weight: | 35,241 Da |
| NCBI Full Name: | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) |
| NCBI Synonym Full Names: | aminoacylase 3 |
| NCBI Official Symbol: | ACY3�� |
| NCBI Official Synonym Symbols: | ACY-3; HCBP1�� |
| NCBI Protein Information: | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) |
| UniProt Protein Name: | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) |
| UniProt Synonym Protein Names: | Acylase III; Aminoacylase-3; ACY-3; Aspartoacylase-2; Hepatitis C virus core-binding protein 1; HCBP1; HCV core-binding protein 1 |
| Protein Family: | N-acyl-aromatic-L-amino acid amidohydrolase |
| UniProt Gene Name: | ACY3�� |
| UniProt Entry Name: | ACY3_HUMAN |
