Description
| Product Name: | Human ACAA1 Recombinant Protein |
| Product Code: | RPPB5764 |
| Size: | 20µg |
| Species: | Human |
| Target: | ACAA1 |
| Synonyms: | ACAA, PTHIO, THIO. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ACAA1 1mg/ml protein solution contains 20mM Tris pH-8, 0.1M NaCl, 1mM DTT & 20% glycerol. |
| Stability: | ACAA1 Human although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLSGAPQASA ADVVVVHGRR TAICRAGRGG FKDTTPDELL SAVMTAVLKD VNLRPEQLGD ICVGNVLQPG AGAIMARIAQ FLSDIPETVP LSTVNRQCSS GLQAVASIAG GIRNGSYDIG MACGVESMSL ADRGNPGNIT SRLMEKEKAR DCLIPMGITS ENVAERFGIS REKQDTFALA SQQKAARAQS KGCFQAEIVP VTTTVHDDKG TKRSITVTQD EGIRPSTTME GLAKLKPAFK KDGSTTAGNS SQVSDGAAAI LLARRSKAEE LGLPILGVLR SYAVVGVPPD IMGIGPAYAI PVALQKAGLT VSDVDIFEIN EAFASQAAYC VEKLRLPPEK VNPLGGAVAL GHPLGCTGAR QVITLLNELK RRGKRAYGVV SMCIGTGMGA AAVFEYPGN |
ACAA1 is part of the thiolase family of enzymes and is takes part in lipid metabolism. ACAA1 enzyme is localized to the peroxisome and catalyzes the conversion of acyl-CoA and acetyl-CoA to 3-oxoacyl-CoA in the fatty acid oxidation pathway. ACAA1 shows high enzymatic activity in liver, kidney, intestine and white adipose tissue in rats. ACAA1 deficiency causes pseudo-Zellweger syndrome.
ACAA1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 419 amino acids (27-424 a.a.) and having a molecular mass of 43.8 kDa. The ACAA1 is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACAA1: an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Lipid Metabolism - unsaturated fatty acid biosynthesis; Lipid Metabolism - fatty acid; Acetyltransferase; EC 2.3.1.16; Amino Acid Metabolism - valine, leucine and isoleucine degradation Chromosomal Location of Human Ortholog: 3p22.2 Cellular Component: peroxisomal matrix; membrane; intracellular membrane-bound organelle; peroxisome Molecular Function:palmitoyl-CoA oxidase activity; protein binding; acetyl-CoA C-acyltransferase activity Biological Process: fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid beta-oxidation; very-long-chain fatty acid metabolic process; bile acid metabolic process; unsaturated fatty acid metabolic process; cellular lipid metabolic process Disease: D-bifunctional Protein Deficiency |
| NCBI Summary: | This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09110 |
| NCBI GenInfo Identifier: | 135751 |
| NCBI Gene ID: | 30 |
| NCBI Accession: | P09110.2 |
| UniProt Secondary Accession: | P09110,Q96CA6, G5E935, |
| UniProt Related Accession: | P09110 |
| Molecular Weight: | 424 |
| NCBI Full Name: | 3-ketoacyl-CoA thiolase, peroxisomal |
| NCBI Synonym Full Names: | acetyl-CoA acyltransferase 1 |
| NCBI Official Symbol: | ACAA1�� |
| NCBI Official Synonym Symbols: | ACAA; THIO; PTHIO�� |
| NCBI Protein Information: | 3-ketoacyl-CoA thiolase, peroxisomal; beta-ketothiolase; peroxisomal 3-oxoacyl-CoA thiolase; acetyl-Coenzyme A acyltransferase 1; peroxisomal 3-oxoacyl-Coenzyme A thiolase |
| UniProt Protein Name: | 3-ketoacyl-CoA thiolase, peroxisomal |
| UniProt Synonym Protein Names: | Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase |
| UniProt Gene Name: | ACAA1�� |
| UniProt Entry Name: | THIK_HUMAN |
