Description
| 抗体名: | HSD17B12 Antibody, Biotin conjugated (PACO36161) |
| 抗体コード: | PACO36161 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Very-long-chain 3-oxoacyl-CoA reductase protein (40-181AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | Catalyzes the second of the four reactions of the long-chain fatty acid, elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acid, /VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid, elongation. Thereby, it may participate to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. |
| シノニム: | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1), HSD17B12, SDR12C1 |
| UniProt Protein Function: | HSD17B12: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Oxidoreductase; Lipid Metabolism - androgen and estrogen; EC 1.1.1.62; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: extracellular matrix; endoplasmic reticulum membrane; integral to membrane Molecular Function:heparin binding; collagen binding; estradiol 17-beta-dehydrogenase activity; protein binding; fibronectin binding Biological Process: extracellular matrix organization and biogenesis; triacylglycerol biosynthetic process; cellular lipid metabolic process; estrogen biosynthetic process; fatty acid biosynthetic process |
| NCBI Summary: | This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q53GQ0 |
| NCBI GenInfo Identifier: | 7705855 |
| NCBI Gene ID: | 51144 |
| NCBI Accession: | NP_057226.1 |
| UniProt Secondary Accession: | Q53GQ0,Q96JU2, Q9Y6G8, A8K9B0, D3DR23, |
| UniProt Related Accession: | Q53GQ0 |
| Molecular Weight: | 34,324 Da |
| NCBI Full Name: | estradiol 17-beta-dehydrogenase 12 |
| NCBI Synonym Full Names: | hydroxysteroid (17-beta) dehydrogenase 12 |
| NCBI Official Symbol: | HSD17B12 |
| NCBI Official Synonym Symbols: | KAR; SDR12C1 |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 12; 17-beta-HSD 12; 17beta-HSD type 12; 3-ketoacyl-CoA reductase; steroid dehydrogenase homolog; 17-beta-hydroxysteroid dehydrogenase 12; short chain dehydrogenase/reductase family 12C, member 1 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 12 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 12; 17-beta-HSD 12; 3-ketoacyl-CoA reductase |
| Protein Family: | Very-long-chain 3-oxoacyl-CoA reductase |
| UniProt Gene Name: | HSD17B12 |
| UniProt Entry Name: | DHB12_HUMAN |
