Description
| 抗体名: | HMGA2 Antibody (PACO21500) |
| 抗体コード: | PACO21500 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Peptide sequence around aa. 6~10(E-G-A-G-Q) derived from Human HMGA2. |
| 憲法: | Liquid |
| ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extract from Hela and 3T3 cells using HMGA2 Antibody. |
| バックグラウンド: | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. |
| シノニム: | HMGIC; HMGI-C; STQTL9; BABL; LIPO |
| UniProt Protein Function: | HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein Chromosomal Location of Human Ortholog: 12q15 Cellular Component: nucleoplasm; nuclear chromosome; nucleus Molecular Function:protein binding; nucleosomal DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; 5'-deoxyribose-5-phosphate lyase activity; SMAD binding; DNA bending activity; transcription factor binding Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; positive regulation of apoptosis; multicellular organismal development; positive regulation of transcription, DNA-dependent; mesodermal cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; chondrocyte differentiation; negative regulation of retroviral genome replication; mitosis; transcription, DNA-dependent; heterochromatin formation; response to virus; DNA damage response, detection of DNA damage; stem cell differentiation; DNA catabolic process, endonucleolytic; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis Disease: Leiomyoma, Uterine |
| NCBI Summary: | This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52926 |
| NCBI GenInfo Identifier: | 1708263 |
| NCBI Gene ID: | 8091 |
| NCBI Accession: | P52926.1 |
| UniProt Related Accession: | P52926 |
| Molecular Weight: | |
| NCBI Full Name: | High mobility group protein HMGI-C |
| NCBI Synonym Full Names: | high mobility group AT-hook 2 |
| NCBI Official Symbol: | HMGA2 |
| NCBI Official Synonym Symbols: | BABL; LIPO; HMGIC; HMGI-C; STQTL9 |
| NCBI Protein Information: | high mobility group protein HMGI-C |
| UniProt Protein Name: | High mobility group protein HMGI-C |
| UniProt Synonym Protein Names: | High mobility group AT-hook protein 2 |
| Protein Family: | HMG2-induced ER-remodeling protein |
| UniProt Gene Name: | HMGA2 |
| UniProt Entry Name: | HMGA2_HUMAN |
| Antibodies | ELISA Kits |
| Anti-HMGA2 Antibody (CAB2972) | Human High mobility group protein HMGI-C ELISA Kit |
| Human High mobility group protein HMGI-C (HMGA2) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
