Description
| 抗体名: | HK3 Antibody (PACO45141) |
| 抗体コード: | PACO45141 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Hexokinase-3 protein (1-270AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO45141 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO45141 at dilution of 1:100. |
| バックグラウンド: | cytosol, fructokinase activity, glucokinase activity, hexokinase activity, mannokinase activity, canonical glycolysis, cellular glucose homeostasis, glucose transport, glycolytic process |
| シノニム: | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III), HK3 |
| UniProt Protein Function: | HK3: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). |
| UniProt Protein Details: | Protein type:Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Enzyme, cellular metabolism; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.1; Kinase, other; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - galactose Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: cytosol Molecular Function:fructokinase activity; glucokinase activity; hexokinase activity; mannokinase activity Biological Process: cell glucose homeostasis; glucose transport; glycolysis |
| NCBI Summary: | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009] |
| UniProt Code: | P52790 |
| NCBI GenInfo Identifier: | 206729871 |
| NCBI Gene ID: | 3101 |
| NCBI Accession: | P52790.2 |
| UniProt Secondary Accession: | P52790,Q8N1E7, |
| UniProt Related Accession: | P52790 |
| Molecular Weight: | 99,025 Da |
| NCBI Full Name: | Hexokinase-3 |
| NCBI Synonym Full Names: | hexokinase 3 |
| NCBI Official Symbol: | HK3 |
| NCBI Official Synonym Symbols: | HXK3; HKIII |
| NCBI Protein Information: | hexokinase-3 |
| UniProt Protein Name: | Hexokinase-3 |
| UniProt Synonym Protein Names: | Hexokinase type III; HK III |
| Protein Family: | Probable histidine kinase |
| UniProt Gene Name: | HK3 |
| UniProt Entry Name: | HXK3_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
