Description
| 抗体名: | HGS Antibody |
| 抗体コード: | PACO00938 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from human Hrs around the non-phosphorylation site of Y334. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | HGS; HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110 |
| UniProt Protein Function: | Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q25 Cellular Component: cytoplasm; cytosol; early endosome; early endosome membrane; endosome; intracellular membrane-bound organelle Molecular Function:metal ion binding; protein binding; protein domain specific binding Biological Process: autophagy; endosome transport; epidermal growth factor receptor signaling pathway; membrane invagination; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; post-Golgi vesicle-mediated transport; protein targeting to lysosome; regulation of MAP kinase activity; regulation of protein catabolic process; signal transduction |
| NCBI Summary: | The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O14964 |
| NCBI GenInfo Identifier: | 71152119 |
| NCBI Gene ID: | 9146 |
| NCBI Accession: | O14964.1 |
| UniProt Secondary Accession: | O14964,Q9NR36, |
| UniProt Related Accession: | O14964 |
| Molecular Weight: | 76,376 Da |
| NCBI Full Name: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
| NCBI Synonym Full Names: | hepatocyte growth factor-regulated tyrosine kinase substrate |
| NCBI Official Symbol: | HGS |
| NCBI Official Synonym Symbols: | HRS |
| NCBI Protein Information: | hepatocyte growth factor-regulated tyrosine kinase substrate |
| UniProt Protein Name: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
| UniProt Synonym Protein Names: | Hrs |
| Protein Family: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
| UniProt Gene Name: | HGS |
| UniProt Entry Name: | HGS_HUMAN |
