Description
| 抗体名: | HEXIM1 Antibody (PACO09713) |
| 抗体コード: | PACO09713 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human HEXIM1 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | hexamethylene bis-acetamide inducible 1;HEXIM1;CLP1;EDG1;FLJ13562;HIS1;MAQ1 ; |
| UniProt Protein Function: | HEXIM1: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. Up-regulated by HMBA (hexamethylene bisacetamide). Down-regulated by estrogen. Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. Belongs to the HEXIM family. |
| UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:cyclin-dependent protein kinase inhibitor activity; protein binding; snRNA binding Biological Process: heart development; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| NCBI Summary: | Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O94992 |
| NCBI GenInfo Identifier: | 74735573 |
| NCBI Gene ID: | 10614 |
| NCBI Accession: | O94992.1 |
| UniProt Secondary Accession: | O94992,B2R8Y5, |
| UniProt Related Accession: | O94992 |
| Molecular Weight: | 40,623 Da |
| NCBI Full Name: | Protein HEXIM1 |
| NCBI Synonym Full Names: | hexamethylene bis-acetamide inducible 1 |
| NCBI Official Symbol: | HEXIM1 |
| NCBI Official Synonym Symbols: | CLP1; EDG1; HIS1; MAQ1 |
| NCBI Protein Information: | protein HEXIM1 |
| UniProt Protein Name: | Protein HEXIM1 |
| UniProt Synonym Protein Names: | Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; Menage a quatre protein 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | HEXIM1 |
| UniProt Entry Name: | HEXI1_HUMAN |
