| UniProt Protein Function: | HEBP2: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin. Belongs to the HEBP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q24 Cellular Component: cytoplasm; mitochondrion Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016] |
| UniProt Code: | Q9Y5Z4 |
| NCBI GenInfo Identifier: | 74753513 |
| NCBI Gene ID: | 23593 |
| NCBI Accession: | Q9Y5Z4.1 |
| UniProt Secondary Accession: | Q9Y5Z4,Q96P57, |
| UniProt Related Accession: | Q9Y5Z4 |
| Molecular Weight: | 20,859 Da |
| NCBI Full Name: | Heme-binding protein 2 |
| NCBI Synonym Full Names: | heme binding protein 2 |
| NCBI Official Symbol: | HEBP2 |
| NCBI Official Synonym Symbols: | PP23; SOUL; C6orf34; C6ORF34B |
| NCBI Protein Information: | heme-binding protein 2 |
| UniProt Protein Name: | Heme-binding protein 2 |
| UniProt Synonym Protein Names: | Placental protein 23; PP23; Protein SOUL |
| Protein Family: | Heme-binding protein |
| UniProt Gene Name: | HEBP2 |
| UniProt Entry Name: | HEBP2_HUMAN |
