| UniProt Protein Function: | HDAC8: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.5.1.98; Hydrolase Chromosomal Location of Human Ortholog: Xq13 Cellular Component: nucleoplasm; nuclear chromosome; histone deacetylase complex; cytoplasm; plasma membrane; cytosol; nucleus Molecular Function:NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; sister chromatid cohesion; mitotic cell cycle; chromatin modification; negative regulation of transcription from RNA polymerase II promoter Disease: Wilson-turner X-linked Mental Retardation Syndrome |
| NCBI Summary: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9BY41 |
| NCBI GenInfo Identifier: | 29839394 |
| NCBI Gene ID: | 55869 |
| NCBI Accession: | Q9BY41.2 |
| UniProt Secondary Accession: | Q9BY41,Q86VC8, Q9NP76, Q9NYH4, A6ND12, A6ND61, A6NET3 A6NJR3, A8MQ62, B4DKN0, B4DV22, |
| UniProt Related Accession: | Q9BY41 |
| Molecular Weight: | 377 |
| NCBI Full Name: | Histone deacetylase 8 |
| NCBI Synonym Full Names: | histone deacetylase 8 |
| NCBI Official Symbol: | HDAC8 |
| NCBI Official Synonym Symbols: | HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1 |
| NCBI Protein Information: | histone deacetylase 8; histone deacetylase-like 1 |
| UniProt Protein Name: | Histone deacetylase 8 |
| UniProt Gene Name: | HDAC8 |
| UniProt Entry Name: | HDAC8_HUMAN |
