Anti-HCFC1 抗体 (PACO21793)

抗体名:	HCFC1 Antibody (PACO21793)
抗体コード:	PACO21793
サイズ:	100ul
宿主種:	Rabbit
申し込み:	ELISA, IHC
推奨される希釈:	ELISA:1:2000-1:10000, IHC:1:50-1:100
反応性:	Human, Mouse
免疫原:	Synthesized peptide derived from N-terminal of human HCFC1.

憲法:	Liquid
ストレージバッファ:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
精製方法:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体のクローン性:	Polyclonal
アイソタイプ:	IgG
Conjugate:	Non-conjugated

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HCFC1 antibody.

バックグラウンド:

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. Kristie T.M., J. Biol. Chem. 270:4387-4394(1995).

シノニム:

TF3C-gamma; TF3C3; TFIIIC 102 kDa subunit; TFIIIC102; TFIIICgamma

UniProt Protein Function:	HCFC1: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xq28 Cellular Component: nucleoplasm; membrane; cell soma; mitochondrion; cytoplasm; nucleus; histone acetyltransferase complex Molecular Function:identical protein binding; protein binding; transcription coactivator activity; chromatin binding; histone acetyltransferase activity (H4-K16 specific); transcription factor activity Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; establishment and/or maintenance of chromatin architecture; protein stabilization; regulation of transcription, DNA-dependent; organelle organization and biogenesis; reactivation of latent virus; positive regulation of cell cycle; regulation of protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell cycle Disease: Methylmalonic Acidemia And Homocysteinemia, Cblx Type
NCBI Summary:	This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:	P51610
NCBI GenInfo Identifier:	160332311
NCBI Gene ID:	3054
NCBI Accession:	P51610.2
UniProt Secondary Accession:	P51610,Q6P4G5,
UniProt Related Accession:	P51610,AAB27583
Molecular Weight:	2035
NCBI Full Name:	Host cell factor 1
NCBI Synonym Full Names:	host cell factor C1
NCBI Official Symbol:	HCFC1
NCBI Official Synonym Symbols:	CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; PPP1R89
NCBI Protein Information:	host cell factor 1; VP16-accessory protein; protein phosphatase 1, regulatory subunit 89
UniProt Protein Name:	Host cell factor 1
UniProt Synonym Protein Names:	C1 factor; CFF; VCAF; VP16 accessory proteinCleaved into the following 12 chains:HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6
Protein Family:	Host cell factor
UniProt Gene Name:	HCFC1
UniProt Entry Name:	HCFC1_HUMAN

Antibodies

Anti-HCFC1 Antibody (CAB16871)

Anti-HCFC1 Antibody (CAB1841)

HCFC1 Antibody (PACO04030)

HCFC1 Antibody (PACO09685)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)