Description
| 抗体名: | H2AFJ Antibody, Biotin conjugated (PACO27296) |
| 抗体コード: | PACO27296 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Histone H2A.J protein (2-129AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| シノニム: | Histone H2A.J (H2a/j), H2AFJ |
| UniProt Protein Function: | H2AFJ: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 12p12.3Cellular Component: nuclear chromatinMolecular Function: DNA bindingBiological Process: chromatin silencing |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015] |
| UniProt Code: | Q9BTM1 |
| NCBI GenInfo Identifier: | 29553970 |
| NCBI Gene ID: | 55766 |
| NCBI Accession: | NP_808760.1 |
| UniProt Secondary Accession: | Q9BTM1,Q9NV63 |
| UniProt Related Accession: | Q9BTM1 |
| Molecular Weight: | 41.3kD |
| NCBI Full Name: | histone H2A.J |
| NCBI Synonym Full Names: | H2A histone family member J |
| NCBI Official Symbol: | H2AFJ |
| NCBI Official Synonym Symbols: | H2AJ |
| NCBI Protein Information: | histone H2A.J |
| UniProt Protein Name: | Histone H2A.J |
| UniProt Synonym Protein Names: | |
| Protein Family: | Histone |
| UniProt Gene Name: | H2AFJ |
| UniProt Entry Name: |
