Description
| 抗体名: | GSTA4 Antibody, HRP conjugated (PACO27222) |
| 抗体コード: | PACO27222 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Glutathione S-transferase A4 protein (1-222AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). |
| シノニム: | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-α member 4) (Glutathione S-transferase A4-4), GSTA4 |
| UniProt Protein Function: | GSTA4: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). Belongs to the GST superfamily. Alpha family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; EC 2.5.1.18; Transferase Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: cytosol Molecular Function:glutathione transferase activity; protein binding; protein homodimerization activity Biological Process: glutathione metabolic process; xenobiotic metabolic process |
| NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15217 |
| NCBI GenInfo Identifier: | 6016167 |
| NCBI Gene ID: | 2941 |
| NCBI Accession: | O15217.1 |
| UniProt Secondary Accession: | O15217,Q5T7Q8, Q6P4G1, Q9BX18, Q9H414, B2RD15, |
| UniProt Related Accession: | O15217 |
| Molecular Weight: | 14,884 Da |
| NCBI Full Name: | Glutathione S-transferase A4 |
| NCBI Synonym Full Names: | glutathione S-transferase alpha 4 |
| NCBI Official Symbol: | GSTA4 |
| NCBI Official Synonym Symbols: | GTA4; GSTA4-4 |
| NCBI Protein Information: | glutathione S-transferase A4 |
| UniProt Protein Name: | Glutathione S-transferase A4 |
| UniProt Synonym Protein Names: | GST class-alpha member 4; Glutathione S-transferase A4-4 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTA4 |
| UniProt Entry Name: | GSTA4_HUMAN |
