Description
| 抗体名: | GRK6 Antibody (PACO43520) |
| 抗体コード: | PACO43520 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| 反応性: | Human, Rat |
| 免疫原: | Recombinant Human G protein-coupled receptor kinase 6 protein (1-170AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: G protein-coupled receptor kinase 6 antibody at 6µg/ml + Rat heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 66, 68, 65 kDa. Observed band size: 66 kDa. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43520 at dilution of 1:100. |
| バックグラウンド: | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| シノニム: | G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6), GRK6, GPRK6 |
| UniProt Protein Function: | GRK6: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Widely expressed. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.11.16; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; GRK subfamily Chromosomal Location of Human Ortholog: 5q35 Cellular Component: membrane Molecular Function:G-protein coupled receptor kinase activity; protein binding; ATP binding Biological Process: Wnt receptor signaling pathway; protein amino acid phosphorylation; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43250 |
| NCBI GenInfo Identifier: | 20141386 |
| NCBI Gene ID: | 2870 |
| NCBI Accession: | P43250.2 |
| UniProt Secondary Accession: | P43250,O60541, Q13652, |
| UniProt Related Accession: | P43250 |
| Molecular Weight: | 64,294 Da |
| NCBI Full Name: | G protein-coupled receptor kinase 6 |
| NCBI Synonym Full Names: | G protein-coupled receptor kinase 6 |
| NCBI Official Symbol: | GRK6 |
| NCBI Official Synonym Symbols: | GPRK6 |
| NCBI Protein Information: | G protein-coupled receptor kinase 6 |
| UniProt Protein Name: | G protein-coupled receptor kinase 6 |
| UniProt Synonym Protein Names: | G protein-coupled receptor kinase GRK6 |
| Protein Family: | G protein-coupled receptor kinase |
| UniProt Gene Name: | GRK6 |
| UniProt Entry Name: | GRK6_HUMAN |
