Description
| 抗体名: | GPSM2 Antibody (PACO09574) |
| 抗体コード: | PACO09574 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human GPSM2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | G-protein signaling modulator 2 (AGS3-like, C. elegans);GPSM2;LGN;Pins ; |
| UniProt Protein Function: | GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family. |
| UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: cell cortex; cytosol Molecular Function:GDP-dissociation inhibitor activity; identical protein binding; protein binding Biological Process: G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis Disease: Chudley-mccullough Syndrome |
| NCBI Summary: | The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P81274 |
| NCBI GenInfo Identifier: | 294862507 |
| NCBI Gene ID: | 29899 |
| NCBI Accession: | P81274.3 |
| UniProt Secondary Accession: | P81274,Q5T1N8, Q6IBL7, Q8N0Z5, |
| UniProt Related Accession: | P81274 |
| Molecular Weight: | 77kDa |
| NCBI Full Name: | G-protein-signaling modulator 2 |
| NCBI Synonym Full Names: | G protein signaling modulator 2 |
| NCBI Official Symbol: | GPSM2 |
| NCBI Official Synonym Symbols: | LGN; CMCS; PINS; DFNB82 |
| NCBI Protein Information: | G-protein-signaling modulator 2 |
| UniProt Protein Name: | G-protein-signaling modulator 2 |
| UniProt Synonym Protein Names: | Mosaic protein LGN |
| Protein Family: | G-protein-signaling modulator |
| UniProt Gene Name: | GPSM2 |
