Description
| 抗体名: | GNAT2 Antibody (PACO22365) |
| 抗体コード: | PACO22365 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human GNAT2. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, using GNAT2 antibody. |
| バックグラウンド: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| シノニム: | ACHM4; GNATC; guanine nucleotide binding protein (G protein); alpha transducing activity 2; guanine nucleotide-binding protein G(t) alpha-2 |
| UniProt Protein Function: | G-alpha t2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4). Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. Belongs to the G-alpha family. G(i/o/t/z) subfamily. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: heterotrimeric G-protein complex; photoreceptor inner segment; photoreceptor outer segment; plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GTP binding; GTPase activity; signal transducer activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; detection of light stimulus involved in visual perception; G-protein signaling, coupled to cAMP nucleotide second messenger; protein folding; Wnt receptor signaling pathway, calcium modulating pathway Disease: Achromatopsia 4 |
| NCBI Summary: | Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19087 |
| NCBI GenInfo Identifier: | 232151 |
| NCBI Gene ID: | 2780 |
| NCBI Accession: | P19087.4 |
| UniProt Related Accession: | P19087 |
| Molecular Weight: | 40,176 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein G(t) subunit alpha-2 |
| NCBI Synonym Full Names: | G protein subunit alpha transducin 2 |
| NCBI Official Symbol: | GNAT2 |
| NCBI Official Synonym Symbols: | ACHM4; GNATC |
| NCBI Protein Information: | guanine nucleotide-binding protein G(t) subunit alpha-2 |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(t) subunit alpha-2 |
| UniProt Synonym Protein Names: | Transducin alpha-2 chain |
| UniProt Gene Name: | GNAT2 |
| UniProt Entry Name: | GNAT2_HUMAN |
