Description
| 抗体名: | GNAO1 Antibody (PACO09510) |
| 抗体コード: | PACO09510 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human GNAO1 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | guanine nucleotide binding protein (G protein), α activating activity polypeptide O;GNAO1;DKFZp686O0962;G-ALPHA-o;GNAO ; |
| UniProt Protein Function: | G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric Chromosomal Location of Human Ortholog: 16q13 Cellular Component: neuron projection; plasma membrane; heterotrimeric G-protein complex Molecular Function:corticotropin-releasing hormone receptor 1 binding; GTPase activity; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to drug; negative regulation of calcium ion transport; response to hydrogen peroxide; muscle contraction; metabolic process; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; response to morphine; locomotory behavior; neurite development; regulation of heart contraction; positive regulation of GTPase activity; aging Disease: Epileptic Encephalopathy, Early Infantile, 17 |
| NCBI Summary: | The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P09471 |
| NCBI GenInfo Identifier: | 232133 |
| NCBI Gene ID: | 2775 |
| NCBI Accession: | P09471.4 |
| UniProt Related Accession: | P09471 |
| Molecular Weight: | |
| NCBI Full Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
| NCBI Synonym Full Names: | G protein subunit alpha o1 |
| NCBI Official Symbol: | GNAO1 |
| NCBI Official Synonym Symbols: | GNAO; NEDIM; EIEE17; HLA-DQB1; G-ALPHA-o |
| NCBI Protein Information: | guanine nucleotide-binding protein G(o) subunit alpha |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
| UniProt Gene Name: | GNAO1 |
| UniProt Entry Name: | GNAO_HUMAN |
