The Glutaredoxin 3 Polyclonal Antibody (CAB5892) is a valuable tool for researchers studying Glutaredoxin 3, a critical enzyme involved in maintaining cellular redox homeostasis. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it a reliable choice for Western blot applications. By binding to the Glutaredoxin 3 protein, researchers can accurately analyze its expression and function in various cell types.Glutaredoxin 3 is known for its role in regulating the cellular redox state by facilitating the reduction of disulfide bonds in proteins. Dysregulation of this enzyme has been linked to oxidative stress-related diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.
Investigating the activity of Glutaredoxin 3 with this antibody is crucial for understanding its contribution to disease pathogenesis and for developing targeted therapies aimed at restoring redox balance in affected cells.Overall, the Glutaredoxin 3 Polyclonal Antibody (CAB5892) is a valuable tool for researchers interested in exploring the role of Glutaredoxin 3 in cellular redox regulation and its implications for human health and disease. Its high specificity and sensitivity make it an essential component of studies in biochemistry, molecular biology, and pharmacology.
Product Name:
GLRX3 Rabbit Polyclonal Antibody
SKU:
CAB5892
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human GLRX3 (NP_001186797.1).
WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3; GLRX3
Positive Sample:
Raji,MCF-7,A-431,HeLa
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Z line, cell cortex, myofibril, sarcomere.
Calculated MW:
37kDa
Observed MW:
37kDa
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
10539
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GLRX3 Rabbit pAb (CAB5892) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
