Description
| 抗体名: | GGA1 Antibody, FITC conjugated (PACO48168) |
| 抗体コード: | PACO48168 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human ADP-ribosylation factor-binding protein GGA1 protein (1-89AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acid, c cluster-dileucine (AC-LL) motif. |
| シノニム: | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, γ ear-containing, ARF-binding protein 1), GGA1 |
| UniProt Protein Function: | GGA1: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Belongs to the GGA protein family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: nucleoplasm; Golgi apparatus; clathrin adaptor complex; intracellular membrane-bound organelle; membrane; endosome membrane Molecular Function:protein binding Biological Process: vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process |
| NCBI Summary: | This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJY5 |
| NCBI GenInfo Identifier: | 14548066 |
| NCBI Gene ID: | 26088 |
| NCBI Accession: | Q9UJY5.1 |
| UniProt Related Accession: | Q9UJY5 |
| Molecular Weight: | |
| NCBI Full Name: | ADP-ribosylation factor-binding protein GGA1 |
| NCBI Synonym Full Names: | golgi associated, gamma adaptin ear containing, ARF binding protein 1 |
| NCBI Official Symbol: | GGA1 |
| NCBI Protein Information: | ADP-ribosylation factor-binding protein GGA1 |
| UniProt Protein Name: | ADP-ribosylation factor-binding protein GGA1 |
| UniProt Synonym Protein Names: | Gamma-adaptin-related protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1 |
| Protein Family: | ADP-ribosylation factor-binding protein |
| UniProt Gene Name: | GGA1 |
| UniProt Entry Name: | GGA1_HUMAN |
