Description
| 抗体名: | GCNT3 Antibody (PACO23392) |
| 抗体コード: | PACO23392 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from internal of human GCNT3. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using GCNT3 antibody. |
 | Immunofluorescence analysis of A549 cells, using GCNT3 antibody. |
| バックグラウンド: | Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. |
| シノニム: | Beta-1; 3-galactosyl-O-glycosyl-glycoprotein beta-1; 6-N-acetylglucosaminyltransferase 3; EC 2.4.1.102; EC 2.4.1.150 |
| UniProt Protein Function: | GCNT3: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Belongs to the glycosyltransferase 14 family. |
| UniProt Protein Details: | Protein type:EC 2.4.1.102; EC 2.4.1.150; Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q21.3 Cellular Component: Golgi membrane; membrane; integral to membrane Molecular Function:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; tissue morphogenesis; O-glycan processing; immunoglobulin production in mucosal tissue; carbohydrate metabolic process; post-translational protein modification; intestinal absorption |
| NCBI Summary: | This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009] |
| UniProt Code: | O95395 |
| NCBI GenInfo Identifier: | 74735588 |
| NCBI Gene ID: | 9245 |
| NCBI Accession: | O95395.1 |
| UniProt Related Accession: | O95395 |
| Molecular Weight: | 50,864 Da |
| NCBI Full Name: | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 |
| NCBI Synonym Full Names: | glucosaminyl (N-acetyl) transferase 3, mucin type |
| NCBI Official Symbol: | GCNT3 |
| NCBI Official Synonym Symbols: | GNTM; C24GNT; C2GNT2; C2GNTM; C2/4GnT |
| NCBI Protein Information: | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; hC2GnT-M; C2GnT-mucin type; beta1,6GlcNAc-transferase; beta1,6-N-acetylglucosaminyltransferase-M; core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase |
| UniProt Protein Name: | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 |
| UniProt Synonym Protein Names: | C2GnT-mucin type; C2GnT-M; hC2GnT-M; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; C2/4GnT |
| Protein Family: | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
| UniProt Gene Name: | GCNT3 |
| UniProt Entry Name: | GCNT3_HUMAN |
