Description
| 抗体名: | GCKR Antibody |
| 抗体コード: | PACO03841 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the Internal region of human GCKR. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | GCKR; Glucokinase regulatory protein; Glucokinase regulator |
| UniProt Protein Function: | GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p23 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:protein binding Biological Process: negative regulation of glucokinase activity; protein import into nucleus, translocation; response to fructose stimulus; urate metabolic process Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5 |
| NCBI Summary: | This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14397 |
| NCBI GenInfo Identifier: | 327478611 |
| NCBI Gene ID: | 2646 |
| NCBI Accession: | Q14397.6 |
| UniProt Secondary Accession: | Q14397,Q53RY6, Q99522, A1L4C2, B4DPQ2, |
| UniProt Related Accession: | Q14397 |
| Molecular Weight: | 16,477 Da |
| NCBI Full Name: | Glucokinase regulatory protein |
| NCBI Synonym Full Names: | glucokinase (hexokinase 4) regulator |
| NCBI Official Symbol: | GCKR |
| NCBI Official Synonym Symbols: | GKRP; FGQTL5 |
| NCBI Protein Information: | glucokinase regulatory protein |
| UniProt Protein Name: | Glucokinase regulatory protein |
| Protein Family: | Glucokinase regulatory protein |
| UniProt Gene Name: | GCKR |
| UniProt Entry Name: | GCKR_HUMAN |
