Description
| 抗体名: | GBA2 Antibody (PACO09422) |
| 抗体コード: | PACO09422 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human GBA2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | glucosidase, β (bile acid, 2;GBA2;AD035;DKFZp762K054;KIAA1605;MGC16895 ; |
| UniProt Protein Function: | GBA2: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo. Belongs to the non-lysosomal glucosylceramidase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.2.1.45; Endoplasmic reticulum; Hydrolase; Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: integral to membrane; plasma membrane; smooth endoplasmic reticulum Molecular Function:beta-glucosidase activity; glucosylceramidase activity Biological Process: bile acid metabolic process; central nervous system neuron development; glycoside catabolic process; glycosphingolipid metabolic process Disease: Spastic Paraplegia 46, Autosomal Recessive |
| NCBI Summary: | This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HCG7 |
| NCBI GenInfo Identifier: | 143018392 |
| NCBI Gene ID: | 57704 |
| NCBI Accession: | Q9HCG7.2 |
| UniProt Secondary Accession: | Q9HCG7,Q5TCV6, Q96A51, Q96LY1, Q96SJ2, Q9H2L8, D3DRP2 |
| UniProt Related Accession: | Q9HCG7 |
| Molecular Weight: | 105kDa |
| NCBI Full Name: | Non-lysosomal glucosylceramidase |
| NCBI Synonym Full Names: | glucosylceramidase beta 2 |
| NCBI Official Symbol: | GBA2 |
| NCBI Official Synonym Symbols: | AD035; SPG46; NLGase |
| NCBI Protein Information: | non-lysosomal glucosylceramidase |
| UniProt Protein Name: | Non-lysosomal glucosylceramidase |
| UniProt Synonym Protein Names: | Beta-glucocerebrosidase 2; Beta-glucosidase 2; Glucosylceramidase 2 |
| UniProt Gene Name: | GBA2 |
