The GALNT14 Polyclonal Antibody (PACO09402) is a valuable tool for research focused on GALNT14, an enzyme involved in protein glycosylation. This antibody, produced in rabbits, is highly specific and reacts strongly with human samples, making it ideal for use in Western blotting and other immunoassays. By targeting the GALNT14 protein, researchers can study its role in various cellular processes and its potential implications in disease development.GALNT14, a member of the glycosyltransferase family, plays a crucial role in protein modification by adding sugar molecules to target proteins.
Dysregulation of GALNT14 has been linked to several diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By studying the function and expression of GALNT14 using this antibody, researchers can gain valuable insights into disease mechanisms and potentially identify new treatment strategies.
GALNT14: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.4.1.41; Transferase; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integralChromosomal Location of Human Ortholog: 2p23.1Cellular Component: Golgi membraneMolecular Function: polypeptide N-acetylgalactosaminyltransferase activityBiological Process: O-glycan processing
UniProt Protein Details:
NCBI Summary:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
