Description
| 抗体名: | GABRA4 Antibody (PACO45345) |
| 抗体コード: | PACO45345 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Gamma-aminobutyric acid, receptor subunit alpha-4 protein (36-258AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO45345 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO45345 at dilution of 1:100. |
| バックグラウンド: | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| シノニム: | Gamma-aminobutyric acid, receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4), GABRA4 |
| UniProt Protein Function: | GABRA4: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, ion channel; Membrane protein, integral; Channel, chloride; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 4p12 Cellular Component: cell junction; integral to plasma membrane; plasma membrane; postsynaptic membrane Molecular Function:benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity Biological Process: central nervous system development; gamma-aminobutyric acid signaling pathway; synaptic transmission; transmembrane transport; transport |
| NCBI Summary: | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P48169 |
| NCBI GenInfo Identifier: | 206729865 |
| NCBI Gene ID: | 2557 |
| NCBI Accession: | P48169.2 |
| UniProt Secondary Accession: | P48169,Q8IYR7, |
| UniProt Related Accession: | P48169 |
| Molecular Weight: | 61,623 Da |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor alpha4 subunit |
| NCBI Official Symbol: | GABRA4 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-4 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-4 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRA4 |
| UniProt Entry Name: | GBRA4_HUMAN |
