Description
| 抗体名: | GABBR1 Antibody (PACO23659) |
| 抗体コード: | PACO23659 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from human GABA B receptor. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemical analysis of paraffin-embedded human brain tissue using GABA B Receptor antibody. |
 | Western blot analysis of extracts from JK cells (Lane 2) and A549 cells (Lane 3), using GABA-B Receptor antiobdy. The lane on the left is treated with synthesized peptide. |
 | Western blot analysis of extracts from HeLa cells, using GABA B Receptor antibody. |
| バックグラウンド: | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. |
| シノニム: | GABABR2; GPR51; G protein-coupled receptor 51; GABA-B RECEPTOR; R2 SUBUNIT |
| UniProt Protein Function: | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. |
| NCBI Summary: | This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9UBS5 |
| NCBI GenInfo Identifier: | 12643873 |
| NCBI Gene ID: | 2550 |
| NCBI Accession: | Q9UBS5.1 |
| UniProt Secondary Accession: | Q9UBS5,O95375, O95468, O95975, O96022, Q5STL4, Q5SUJ8 Q5SUL3, Q71SG6, Q86W60, Q9UQQ0, B0UXY7, |
| UniProt Related Accession: | Q9UBS5 |
| Molecular Weight: | 65,082 Da |
| NCBI Full Name: | Gamma-aminobutyric acid type B receptor subunit 1 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type B receptor subunit 1 |
| NCBI Official Symbol: | GABBR1 |
| NCBI Official Synonym Symbols: | GB1; GPRC3A; GABABR1; GABBR1-3 |
| NCBI Protein Information: | gamma-aminobutyric acid type B receptor subunit 1 |
| UniProt Protein Name: | Gamma-aminobutyric acid type B receptor subunit 1 |
| Protein Family: | Gamma-aminobutyric acid type B receptor |
| UniProt Gene Name: | GABBR1 |
| UniProt Entry Name: | GABR1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
