Description
| 抗体名: | FZD9 Antibody (PACO48910) |
| 抗体コード: | PACO48910 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Frizzled-9 protein (23-229AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse liver tissue, Mouse kidney tissue. All lanes: FZD9 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 65 kDa. Observed band size: 65 kDa.. |
 | IHC image of PACO48910 diluted at 1:500 and staining in paraffin-embedded human thyroid tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| バックグラウンド: | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| シノニム: | Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349), FZD9, FZD3 |
| UniProt Protein Function: | FZD9: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. |
| UniProt Protein Details: | Protein type:GPCR, Fz/Smo family; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: cell surface; cytoplasm; plasma membrane Molecular Function:G-protein coupled receptor activity; protein heterodimerization activity; protein homodimerization activity; Wnt-protein binding Biological Process: nervous system development; Wnt receptor signaling pathway through beta-catenin |
| NCBI Summary: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00144 |
| NCBI GenInfo Identifier: | 17432964 |
| NCBI Gene ID: | 8326 |
| NCBI Accession: | O00144.1 |
| UniProt Related Accession: | O00144 |
| Molecular Weight: | 64,466 Da |
| NCBI Full Name: | Frizzled-9 |
| NCBI Synonym Full Names: | frizzled class receptor 9 |
| NCBI Official Symbol: | FZD9 |
| NCBI Official Synonym Symbols: | FZD3; CD349 |
| NCBI Protein Information: | frizzled-9 |
| UniProt Protein Name: | Frizzled-9 |
| UniProt Synonym Protein Names: | FzE6; CD_antigen: CD349 |
| Protein Family: | Frizzled |
| UniProt Gene Name: | FZD9 |
| UniProt Entry Name: | FZD9_HUMAN |
| Antibodies |
| Anti-Frizzled-9 Antibody (CAB8311) |
| FZD9 Antibody (PACO00825) |
| FZD9 Antibody (PACO05448) |
| FZD9 Antibody (PACO07367) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
