Description
| 抗体名: | FZD3 Antibody (PACO06490) |
| 抗体コード: | PACO06490 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | ELISA:1:10000, WB:1:500-1:2000, IF:1:200-1:1000 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from the Internal region of human Frizzled-3. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of A549 cells using Frizzled-3 Polyclonal Antibody. |
 | Western Blot analysis of RAW264.7 cells using Frizzled-3 Polyclonal Antibody. |
| シノニム: | FZD3; Frizzled-3; Fz-3; hFz3 |
| UniProt Protein Function: | FZD3: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8p21 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; PDZ domain binding; protein binding; Wnt receptor activity; Wnt-protein binding Biological Process: negative regulation of mitotic cell cycle, embryonic; neuron differentiation; positive regulation of neuroblast proliferation; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway |
| NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9NPG1 |
| NCBI GenInfo Identifier: | 17433071 |
| NCBI Gene ID: | 7976 |
| NCBI Accession: | Q9NPG1.1 |
| UniProt Secondary Accession: | Q9NPG1,A8K615, |
| UniProt Related Accession: | Q9NPG1 |
| Molecular Weight: | – Da |
| NCBI Full Name: | Frizzled-3 |
| NCBI Synonym Full Names: | frizzled class receptor 3 |
| NCBI Official Symbol: | FZD3 |
| NCBI Official Synonym Symbols: | Fz-3 |
| NCBI Protein Information: | frizzled-3 |
| UniProt Protein Name: | Frizzled-3 |
| UniProt Gene Name: | FZD3 |
| UniProt Entry Name: | FZD3_HUMAN |
| Antibodies | ELISA Kits |
| Anti-FZD3 Antibody (CAB10063) | Human FZD3 / Frizzled-3 ELISA Kit |
| FZD3 Antibody (PACO05375) | Human Frizzled-3 (FZD3) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
