Description
| 抗体名: | FZD10 Antibody |
| 抗体コード: | PACO01981 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Mouse |
| 免疫原: | synthesized peptide derived from the N-terminal region of human Frizzled-10. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | FZD10; Frizzled-10; Fz-10; hFz10; FzE7; CD350 |
| UniProt Protein Function: | FZD10: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, Fz/Smo family; Receptor, GPCR Chromosomal Location of Human Ortholog: 12q24.33 Cellular Component: cell surface; cytoplasm; integral to plasma membrane Molecular Function:G-protein coupled receptor activity; protein binding; Wnt-protein binding Biological Process: neuron differentiation; positive regulation of GTPase activity; positive regulation of JNK activity; regulation of actin cytoskeleton organization and biogenesis; Wnt receptor signaling pathway through beta-catenin |
| NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULW2 |
| NCBI GenInfo Identifier: | 17433091 |
| NCBI Gene ID: | 11211 |
| NCBI Accession: | Q9ULW2.1 |
| UniProt Related Accession: | Q9ULW2 |
| Molecular Weight: | 65,336 Da |
| NCBI Full Name: | Frizzled-10 |
| NCBI Synonym Full Names: | frizzled class receptor 10 |
| NCBI Official Symbol: | FZD10 |
| NCBI Official Synonym Symbols: | Fz10; FzE7; CD350; FZ-10; hFz10 |
| NCBI Protein Information: | frizzled-10 |
| UniProt Protein Name: | Frizzled-10 |
| UniProt Synonym Protein Names: | FzE7; CD_antigen: CD350 |
| Protein Family: | Frizzled |
| UniProt Gene Name: | FZD10 |
| UniProt Entry Name: | FZD10_HUMAN |
